MG132 Induces Expression of Monocyte Chemotactic Protein-Induced Protein 1 in Vascular Smooth Muscle Cells

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成果类型：

期刊论文

作者：

Tan, Xi;Gao, Jie;Shi, Zhan;Tai, Shi;Chan, Leona Loretta;...

通讯作者：

Zheng, Xi-Long

作者机构：

[Jiang, Zhi-Sheng; Tan, Xi; Tai, Shi; Zheng, Xi-Long; Shi, Zhan; Chan, Leona Loretta] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol,Smooth Muscle Res Grp, Calgary, AB, Canada.

[Tan, Xi; Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

[Gui, Yu; Gao, Jie] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada.

[Peng, Dao-Quan; Yang, Yang] Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha, Hunan, Peoples R China.

[Jiang, Zhi-Sheng] Univ South China, Inst Cardiovasc Dis, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zheng, Xi-Long] U

Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Calgary, AB T2N 4Z6, Canada.

语种：

英文

期刊：

Journal of Cellular Physiology

ISSN：

0021-9541

年：

2017

卷：

232

期：

页码：

122-128

DOI：

10.1002/jcp.25396

基金类别：

Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR) [MOP-119511]; Heart and Stroke Foundation of CanadaHeart & Stroke Foundation of Canada; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371161]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Monocyte chemoattractant protein-1 (MCP-1) has been reported to induce the expression of monocyte chemotactic protein-induced protein 1 (MCPIP1), which undergoes ubiquitination degradation. Therefore, we predict that in vascular smooth muscle (VSMCs), MCPIP1 may be induced by MCP-1 and undergo degradation, which can be inhibited by the proteasome inhibitor, MG132. Our results showed that treatment of human VSMCs with MCP-1 did not increase the expression of MCPIP1. Treatment with MG132, however, elevated MCPIP1 protein levels through stimulatio...

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MG132 Induces Expression of Monocyte Chemotactic Protein-Induced Protein 1 in Vascular Smooth Muscle Cells

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