期刊论文

中文

中国医药导报

1673-7210

2015

12

13

19-22+169

湖南省中医药科研计划项目（60010287）；

本校为第一机构

目的 研究护心康对大鼠动脉粥样硬化防治的作用机制.方法 采用高脂喂饲及一次性腹腔注射维生素D3复制大鼠动脉粥样硬化模型,将护心康分为低、中、高3个不同剂量组进行干预治疗,通过免疫组化法检测给药后主动脉中核转录因子-κB(NF-κB)、血管细胞黏附分子-1(VCAM-1)及单核细胞趋化蛋白-1(MCP-1)的表达情况.结果 护心康低、中、高剂量组均有较好的降低动脉粥样硬化大鼠主动脉中NF-κB、VCAM-1及MCP-1表达的作用(P＜0.01),其中NF-κB、VCAM-1的表达显示出护心康中、高剂量组作用优于低剂量组,差异有统计学意义[NF-κB:(0.23600±0.015 17)、(0.172 00±0.024 90)比(0.406 00±0.070 21);VCAM-1:(0...

Objective To explore the mechanism of Huxinkang （HXK） on prevention of rats with atherosclerosis （AS）.Methods The rats were fed with high cholesterol diet and given disposable intraperitoneal injection of vitamin D3 to induce the models,then,they were treated by low,middle and high dose of HXK.The levels of nuclear factor gene binding （NF-κB）,vascular cell adhesion molecule-1 （VCAM-1） and monocyte chemoattractant protein-1 （MCP-1） on aortic of AS rats were examined by immunohistochemistry in each group.Results All the low,middle and ...