期刊论文

Experimental study on the effect of Astragalus and vine decoction on the expression of vascular endothelial growth factor and receptor mRNA in peripheral tissues of ischemic stroke rats

中文

临床和实验医学杂志

1671-4695

2018

17

22

2367-2370

10.3969/j.issn.1671-4695.2018.22.005

湖南省教育厅高校科研项目（编号:15C1034）；

本校为第一机构

目的实验研究黄芪虫藤饮对缺血性脑卒中大鼠梗死灶周围组织血管内皮生长因子（VEGF）及受体（Flk-1） mRNA表达的调节作用。方法选取SD雄性大鼠88只,通过线栓法来制备脑缺血大鼠模型,依据随机数字表法将大鼠分为两组,观察组（44只）,对照组（44只）;观察组大鼠在手术以后2 h起使用黄芪虫藤饮药液灌胃,每天两次,对照组同剂量、同时间使用清水灌胃。采用RT-PCR法检测梗死灶周边Flk-1及VEGF mRNA表达情况。结果不同时间点观察组大鼠Flk-1 mRNA与VEGF表达量对比差异有统计学意义（P 0. 14）,第6～12天和第12～24天降低速度较对照组慢（斜率α,-0. 12>-0. 14,-0. 22>-0. 30）。结论黄芪虫藤饮可能经过...

Objective To study the eft）ct of Astragalus vine decoction on the expression of vascular endothelial growth factor （VEGF） and mRNA （ Flk - 1 ） in peripheral tissues of isehenfie stroke rats. Methods 88 male SD rats were selected, rat cerebral isehenfia model was prepared by suture method, according to the random number table method, the rats were divided into two groups, observation group （44 rats） , control group （44 rats） ; observation group rats, two hours after operation, were given Astragalus bug cane drink oral liquid, two times ...