期刊论文

中文

临床和实验医学杂志

1671-4695

2020

19

24

2581-2585

10.3969/j.issn.1671-4695.2020.24.002

湖南省教育厅课题项目(编号:19C1431)。

本校为第一机构

目的探讨血速升颗粒对大鼠心肌缺血再灌注损伤（MIRI）后的心功能保护作用及机制。方法 75只雄性SD大鼠随机数字表法分为假手术组、模型组、血速升颗粒低剂量组、血速升颗粒高剂量组和辛伐他汀组,每组15只。除假手术组,其余各组大鼠制备心肌I/R模型,术后24 h,血速升颗粒低、高剂量组大鼠分别以1、5 g/kg剂量灌胃给药,辛伐他汀组大鼠以20 mg/kg剂量灌胃给药,每天1次,连续给药4周。超声成像系统评估大鼠心脏功能,全自动生化分析仪检测血清肌酸激酶（CK）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）、丙二醛（MDA）的变化,TTC染色检测心肌梗死面积,HE染色观察心肌组织病理学改变,TUNEL染色检测心肌...

Objective To explore the protective effect and mechanism of Xuesusheng granule on cardiac function after myocardial ischemia-reperfusion injury(MIRI)in rats.Methods Seventy-five male SD rats were randomly divided into sham operation group,model group,Xuesusheng granule low-dose group,Xuesusheng granule high-dose group and simvastatin group,15 rats in each group.Except for the sham operation group,the rats in the remaining groups were prepared with myocardial I/R models.At 24 h after surgery,the low-dose group and high-dose group were given 1,5 ...