Exosomes Derived hsa-miR-4669 as a Novel Biomarker for Early Predicting the Response of Subcutaneous Immunotherapy in Pediatric Allergic Rhinitis

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成果类型：

期刊论文

作者：

Jiang, Sijie;Xie, Shaobing;Fan, Ruohao;Tang, Qingping;Zhang, Hua;...

通讯作者：

Weihong Jiang

作者机构：

[Fan, Ruohao; Xie, Shumin; Gao, Kelei; Xie, Shaobing; Zhang, Hua; Wang, Fengjun; Jiang, Sijie; Zhang, Junyi; Xie, Zhihai; Jiang, Weihong] Cent South Univ, Dept Otolaryngol Head & Neck Surg, Xiangya Hosp, Changsha, Peoples R China.

[Fan, Ruohao; Xie, Shumin; Gao, Kelei; Xie, Shaobing; Zhang, Hua; Wang, Fengjun; Jiang, Sijie; Zhang, Junyi; Xie, Zhihai; Jiang, Weihong] Cent South Univ, Hunan Prov Key Lab Otolaryngol Crit Dis, Xiangya Hosp, Changsha, Peoples R China.

[Fan, Ruohao; Xie, Shumin; Gao, Kelei; Xie, Shaobing; Zhang, Hua; Wang, Fengjun; Jiang, Sijie; Zhang, Junyi; Xie, Zhihai; Jiang, Weihong] Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha, Peoples R China.

[Tang, Qingping] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Dept Rehabil, Changsha, Peoples R China.

通讯机构：

[Weihong Jiang] D

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People’s Republic of China<&wdkj&>Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People’s Republic of China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People’s Republic of China

语种：

英文

关键词：

allergic rhinitis;subcutaneous immunotherapy;miRNA;exosome;children

期刊：

Journal of Inflammation Research

ISSN：

1178-7031

年：

2022

卷：

期：

Volume 15, 2022 - Issue

页码：

5063-5074

DOI：

10.2147/JIR.S379414

基金类别：

This work was supported by the National Natural Science Foundation of China (No.82171118) and the Provincial Natural Science Foundation of Hunan (2022JJ30327).

机构署名：

本校为其他机构

院系归属：

针灸推拿与康复学院

摘要：

PURPOSE: Subcutaneous immunotherapy (SCIT) is an effective treatment for pediatric allergic rhinitis (AR), but its efficacy fluctuates among individuals. This study aims to identify the profile of serum exosomes derived microRNAs (miRNAs) and evaluate their capacities to early predict SCIT efficacy in pediatric AR. PATIENTS AND METHODS: High-throughput sequencing was applied to identify the miRNA of serum exosomes in AR children. GO enrichment and KEGG pathway analysis were performed to enrich the biological annotations of target mRNAs of miRNAs. Then we validated differentially expressed miRN...

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Exosomes Derived hsa-miR-4669 as a Novel Biomarker for Early Predicting the Response of Subcutaneous Immunotherapy in Pediatric Allergic Rhinitis

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