Network Pharmacology Combined with Bioinformatics to Investigate the Mechanisms and Molecular Targets of Astragalus Radix-Panax notoginseng Herb Pair on Treating Diabetic Nephropathy

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成果类型：

期刊论文

作者：

Zhao, Jie;Mo, Chao;Shi, Wei;Meng, LiFeng;Ai, Jun

作者机构：

[Zhao, Jie] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.

[Shi, Wei; Meng, LiFeng; Mo, Chao] Guangxi Univ Chinese Med, Dept Nephrol, Affiliated Hosp 1, Nanning 530023, Guangxi, Peoples R China.

[Meng, LiFeng] Southwest Med Univ, Tradit Chinese & Western Med Lab Controlling Orga, Luzhou 646000, Sichuan, Peoples R China.

[Ai, Jun] Guangxi Univ Chinese Med, Basic Med Sch, Nanning 530200, Guangxi, Peoples R China.

语种：

英文

期刊：

Evidence-Based Complementary and Alternative Medicine

ISSN：

1741-427X

年：

2021

卷：

2021

DOI：

10.1155/2021/9980981

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81860838]; Postdoctoral Science Foundation of ChinaChina Postdoctoral Science Foundation [2017M612987]; Studio of Shi Wei for the Heritage of Famous Traditional Chinese Medicine Practitioners [[2017] 2]

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本校为第一机构

院系归属：

研究生院

摘要：

Background. Astragalus Radix (AR)-Panax notoginseng (PN), a classical herb pair, has shown significant effects in treating diabetic nephropathy (DN). However, the intrinsic mechanism of AR-PN treating DN is still unclear. This study aims to illustrate the mechanism and molecular targets of AR-PN treating DN based on network pharmacology combined with bioinformatics. Materials and Methods. The Traditional Chinese Medicine Systems Pharmacology database was used to screen bioactive ingredients of AR-PN. Subsequently, putative targets of bioactive ingredients were predicted utilizing the DrugBank ...

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Network Pharmacology Combined with Bioinformatics to Investigate the Mechanisms and Molecular Targets of Astragalus Radix-Panax notoginseng Herb Pair on Treating Diabetic Nephropathy

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