期刊论文

中文

陕西中医药大学学报

2096-1340

2019

42

3

68-72,111

10.13424/j.cnki.jsctcm.2019.03.019

81573686:国家自然科学基金 81373708:国家自然科学基金

本校为第一机构

目的 探索脾虚痰湿型肥胖大鼠模型的制备方法.方法 24只SD雄性大鼠按体重随机分为正常组(n=8)、模型A组(n=8)、模型B组(n=8).模型A、B两组采用不同的干预顺序,观察各组大鼠一般行为学的变化情况及毛色、大便、体质量、精神状态、计算脾虚积分;测定大鼠总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)并观察肝脏病理变化.结果 经过高脂饲料喂养,模型组体重超过正常组(P＜0.05);经过造模干预后模型组大鼠形体肥胖、被毛油腻、活动迟缓、倦怠蜷卧、大便稀软,符合脾虚痰湿的一般表现;模型A、B组均有不同程度的脂肪肝,且模型A组大鼠出现肝功能损...

Objective To explore preparing method of obese rat model with spleen deficiency and phlegm dampness. Methods Twenty-four SD male rats were randomly divided into normal group ( n = 8), model A group ( n = 8) and model B group ( n = 8). Models A and B were treated with different intervention sequences. The general behavioral changes and hair color, stool, body mass, mental state, and spleen deficiency scores were observed. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol ( HDL-C), low density lipoprotein cholesterol ( LDL-C), glutathione transaminase ( ALT) were me...