Dipsacoside B ameliorates cognitive impairment in sepsis-associated encephalopathy by reducing Th17 cell infiltration and neuroinflammation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Peng, Sha;Sun, Taoli;Yang, Dongmei;Zhao, Hongqing;Lin, Limei;...

通讯作者：

Shi, Zhe;Tuo, Q

作者机构：

[Lin, Limei; Tuo, Qinhui; Xia, Bohou; Sun, Taoli; Shi, Zhe; Shi, Z; Peng, Sha; Yang, Dongmei; Li, Minjie] Hunan Univ Chinese Med, Sch Pharm, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

[Tuo, Qinhui; Sun, Taoli; Peng, Sha; Yang, Dongmei; Piao, Meihong] Hunan Univ Chinese Med, Key Lab Vasc Biol & Translat Med, Changsha 410208, Hunan, Peoples R China.

[Tuo, Qinhui; Yang, Dongmei; Piao, Meihong] Hunan Univ Chinese Med, Basic Res Ctr Integrated Chinese & Western Med Pre, Med Sch, Changsha 410208, Hunan, Peoples R China.

[Zhao, Hongqing] Hunan Univ Chinese Med, Sci & Technol Innovat Ctr, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Tuo, Q ; Shi, Z] H

Hunan Univ Chinese Med, Sch Pharm, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Key Lab Vasc Biol & Translat Med, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Basic Res Ctr Integrated Chinese & Western Med Pre, Med Sch, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Cognitive impairment;Dipsacoside B;Neuroinflammation;Sepsis-associated encephalopathy;Th17 cell

期刊：

Biochemical Pharmacology

ISSN：

0006-2952

年：

2024

卷：

227

页码：

116428

DOI：

10.1016/j.bcp.2024.116428

基金类别：

Scientific Research Fund of Hunan Provincial Education [22A0276]; Project of Discipline Construction at Hunan University of Chinese Medicine [22JBZ039]; Key Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine [202302]; Open Fund Project of National Key Laboratory Cultivation Base of Chinese Medicinal Powder & Innovative Medicinal [23PTKF1009]; Key Research and Development Projects of Hunan Provincial Science and Technology Department [2022SK2011]; Science and Technology Innovation Program of Hunan Province [2021RC4064]; Excellent Youth Project of Hunan Provincial Department of Education [22B0387]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学院

摘要：

Sepsis-associated encephalopathy (SAE) is the main cause of cognitive impairment in patients with sepsis. The infiltration of inflammatory signals into the central nervous system (CNS) via the compromised blood-brain barrier (BBB) represents a crucial step in the pathological progression of SAE. In particular, T-helper 17 cell (Th17 cells) has been suggested to be highly correlated with the activation of central immune responses. Thus, preventing Th17 cell infiltration into the CNS may be a possible strategy to alleviate cognitive decline in SAE. Dipsacoside B (DB) is one of the primary active...

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Dipsacoside B ameliorates cognitive impairment in sepsis-associated encephalopathy by reducing Th17 cell infiltration and neuroinflammation

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