期刊论文

Yang, S

英文

Naunyn-Schmiedeberg's Archives of Pharmacology

0028-1298

2023

1-16

10.1007/s00210-023-02750-9

Thanks to Professor Shuo Yang for her foundation support for this study. And this study was supported by the National Natural Science Foundation of China (81503611), the Natural Science Foundation of Hunan Province (2020JJ5427), and the Hunan Provincial Department of Education Excellent Youth Fund Project (20B428).

本校为第一且通讯机构

To examine the effects of clomiphene citrate (CC) on follicular fluid metabolites and related metabolic pathways in rats with polycystic ovary syndrome (PCOS) using non-targeted metabolomics and determine how CC treats ovulation disorder in PCOS. The Sprague Dawley rats were randomly divided into control, model, and CC groups. A PCOS model was established with letrozole. Body weight, ovarian weight, estrus cycles, serum hormone levels, and ovary histopathology of the rats were collected for further evaluation. Moreover, through ultra-performanc...