High mobility group box- l （HMGB1） distributed widely. It exists in many organs. HMGB1 locates in nuclei and cytoplasm in normal condition. It involves in many activity of life （ i. e. , duplication of DNA, cellular differentiation, gene expression）. The immunocytes （i. e. , mononuclear macrophage and dendritic cells） secrete HMGB1 into the extracellular milieu when stimulated with LPS and cytokines. It acts as proinflammatory cytokines, activates inflammatory and immunological responses. As a late mediators of inflammation and last long,...
