Actinidia eriantha polysaccharide prevents gastric cancer invasion and metastasis via inhibition of PD-1/PD-L1 regulation of macrophage polarization

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成果类型：

期刊论文

作者：

Li, Jinxia;Gao, Kun;Liu, Ying;Ning, Zixin;Yang, Xiaoyu;...

通讯作者：

Shen, L;Chen, W

作者机构：

[Li, Jinxia] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.

[Li, Jinxia] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha 410208, Peoples R China.

[Shen, Li; Ning, Zixin; Yang, Xiaoyu; Gao, Kun] China Acad Chinese Med Sci, Inst Basic Theory TCM, Beijing 100700, Peoples R China.

[Liu, Ying] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.

[Chen, Wei; Chen, W] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310016, Peoples R China.

通讯机构：

[Shen, L ] C

[Chen, W ] Z

China Acad Chinese Med Sci, Inst Basic Theory TCM, Beijing 100700, Peoples R China.

Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310016, Peoples R China.

语种：

英文

关键词：

Actinidia eriantha polysaccharide;Macrophage;Gastric cancer

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2025

卷：

304

期：

Pt 1

页码：

140763

DOI：

10.1016/j.ijbiomac.2025.140763

基金类别：

Scientific and Techno-logical Innovation Project of China Academy of Chinese Medical Science [CI2021A03809]; National Natural Science Foundation of China [82074398, 82104775]; Special Funds for Basic Research Expenses of Central Public Welfare Research Institutes [YZX-202407]; TCM Theory Inheritance and Innovation Project of CACMS Innovation Fund [KYG-202406]; Science and Technology Innovation Program of Hunan Province [2024RC3198]; Young Elite Scientists Sponsorship Program by China Association for Science and Technology [YESS20220451]; Outstanding Youth Program of Hunan University of Traditional Chinese Medicine [Z2023XJYQ04]

机构署名：

本校为第一机构

院系归属：

中医学院

中医诊断研究所

摘要：

Actinidia eriantha polysaccharide (AEPS), an active component of the Chinese herbal medicine Radix Actinidia chinensis , has anticancer effects. Here, we investigated the therapeutic potential of AEPS in gastric cancer through in vivo, in vitro, and in silico analyses. In our gastric cancer xenograft mouse model, AEPS effectively reduced tumor volume and weight. In the human gastric adenocarcinoma cell line AGS, AEPS inhibited migration and invasion without affecting proliferation; this result was validated in a fluorescent-labeled lung metasta...

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Actinidia eriantha polysaccharide prevents gastric cancer invasion and metastasis via inhibition of PD-1/PD-L1 regulation of macrophage polarization

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