期刊论文

Chen, XY;Cai, HZ

英文

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

0393-974X

2023

37

3

1381-1391

10.23812/j.biol.regul.homeost.agents.20233703.138

Construction Project of Chen Xinyu Inheritance Studio-National Famous Traditional Chinese Medicine Expert (Department of Chinese Medicine Education in China) [2020TJ-N01]; National Natural Science Foundation of China [81704061, 81173213]; Hunan province innovative province construction special fight against new coronavirus pneumonia project [2020SK3009]; Hunan Development and Reform Commission Innovation Guidance Project (Hunan Development and Reform Investment) [2022-75]; Special Project for the Construction of Key Laboratory of "Four Seasons Adjusting Yang" for Heart Disease (Xiang TCM Letter 51); Hunan Engineering Research Center for Preventive Treatment of Diseases in "Four Seasons Adjusting Yang" (Hunan Development to High Technology) [2022ZYX01]; Hunan University of Traditional Chinese Medicine first-class discipline open fund; R&D plan for key areas of Hunan Provincial Department of Science and Technology; Hunan science and technology talent hosting project; [2019-412]; [1006]; [2022ZYX11]; [2021ZYX41]; [2019SK2321]

本校为第一且通讯机构

Objectives: To explore how the mechanism of miR-18a-5p overexpression through the Notch signaling pathway improves cardiac function and inhibits cardiomyocyte apoptosis in chronic heart failure rats. Methods: Forty rats were randomly divided into contrast group, negative control (NC) group, high-expression group, and low -expression group by random number table, with ten rats in each group. NC group rats, high-expression group rats, and low -expression group rats were injected intraperitoneally with 2 mg/mL adriamycin solution to establish the rat model of chronic heart failure. The miR-18a-5p...