The article analyzed the impact of cultural differences factors and non-cultural fac- tors on cross-cultural adaptation of Pakistani medical students from the following aspects : daily habits, language, religion, values, China~s laws and regulations, service mode of social life, curriculum set- ting, universities' management mode, adolescent growth factors, learning methods and learning ability, higher education and primary education teaching methods, difference between traditional and modern Chinese. Some recommendations were given from several aspects, such as ...