Cytotoxicity of Schisandronic Acid from Kadsura coccinea by Activation of Caspase-3, Cleavage of poly-ADP Ribose Polymerase, and Reduction of Oxidative Stress

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成果类型：

期刊论文

作者：

Tasneem, Shumaila*;Yang, Yupei;Liu, Bin;Choudhary, M. Iqbal;Wang, Wei

通讯作者：

Tasneem, Shumaila;Wang, W;Tasneem, S

作者机构：

[Tasneem, Shumaila; Liu, Bin; Yang, Yupei; Choudhary, M. Iqbal; Wang, Wei; Tasneem, S] Hunan Univ Chinese Med, Tradit Chinese Med & Ethnomed Innovat & Dev Int L, Tradit Chinese Med & Ethnomed Res Ctr, Innovat Drug Res Inst,Sch Pharm, Changsha 410208, Peoples R China.

[Tasneem, Shumaila; Choudhary, M. Iqbal; Tasneem, S] Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan.

[Liu, Bin] Hunan Univ, State Key Lab, Hunan Prov Key Lab Plant Funct Genom & Dev Regula, Coll Biol, Changsha 410082, Peoples R China.

通讯机构：

[Wang, W ; Tasneem, S] H

[Tasneem, S ] U

Hunan Univ Chinese Med, Tradit Chinese Med & Ethnomed Innovat & Dev Int L, Tradit Chinese Med & Ethnomed Res Ctr, Innovat Drug Res Inst,Sch Pharm, Changsha 410208, Peoples R China.

Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan.

语种：

英文

关键词：

Chemiluminescence;Cytotoxicity;MCF-7 cell line;MTT assay;NADPH oxidase;Triterpenoid

期刊：

Revista Brasileira de Farmacognosia

ISSN：

0102-695X

年：

2021

卷：

期：

页码：

51-58

DOI：

10.1007/s43450-021-00136-7

基金类别：

Financial support was provided by the Hunan Province Universities 2011 collaborative Innovation Center of Protection and Utilization of Huxiang Chinese Medicine Resources, Hunan Provincial Key Laboratory of Diagnostics in Chinese Medicine and National Natural Science Foundation of China (81673579 and 81874369), Talented Young Scientist Program for developing countries, Ministry of Science and Technology, China, and Shaanxi innovative talents promotion plan and technological innovation team (2018TD-005).

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Breast cancer is an invasive malignant neoplasm; however, an increasing number of naturally occurring chemical compounds have been identified as potent cytotoxic agents. Kadsura coccinea (Lem.) A.C.Sm., Schisandraceae, is a medicinally important Chinese plant. Schisandronic acid, a cycloartane triterpenoid, is a major cytotoxic compound from this plant. The mechanisms behind the cytotoxic potential of schisandronic acid against a human breast carcinoma cell line were evaluated by employing cell viability assay using MTT and western blot analysis. Antioxidant capacity was measured by employing ...

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Cytotoxicity of Schisandronic Acid from Kadsura coccinea by Activation of Caspase-3, Cleavage of poly-ADP Ribose Polymerase, and Reduction of Oxidative Stress

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