Dual-sensitive antibacterial peptide nanoparticles prevent dental caries

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成果类型：

期刊论文

作者：

Zhang, Peng;Wu, Saizhi;Li, Jinting;Bu, Xiaoshuang;Dong, Xiaoping;...

作者机构：

[Zhang, Peng; Chen, Ninglin; Dong, Xiaoping; Li, Jinting; Li, Fengjiao; Liang, Songping; Zhu, Jingyu; Wu, Saizhi; Sang, Longkang; Liu, Zhonghua] Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha, Hunan, Peoples R China.

[Chen, Ninglin; Yu, Zhilin] Nankai Univ, Coll Chem, Key Lab Funct Polymer Mat, Minist Educ, Tianjin, Peoples R China.

[Bu, Xiaoshuang] Hunan Univ Chinese Med Changsha, Changsha Stomatol Hosp, Sch Dent Med, Dept Periodontol & Pediat Dent, Changsha, Hunan, Peoples R China.

[Zhang, Peng; Zeng, Youlin] Hunan Normal Univ, Coll Chem & Chem Engn, Natl & Local Joint Engn Lab New Petrochem Mat & F, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

antimicrobial peptides;stimuli-responsive;conformational transition;nanoparticles;biofilms;dental caries

期刊：

Theranostics

ISSN：

1838-7640

年：

2022

卷：

期：

页码：

4818-4833

DOI：

10.7150/thno.73181

基金类别：

Science and Technology Innovation Program of Hunan Province [2020RC2051, 2020RC4023]; National Nature Sciences Foundation of China [31570782, 31770832, 31872718, 32071262, 81970493]; Natural Science Foundation of Hunan province [2021JJ40335]; China Postdoctoral Science Foundation [2020M682576]

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本校为其他机构

摘要：

Background: Dental caries is the most prevalent bacterial biofilm-induced disease. Current clinical prevention and treatment agents often suffer from adverse effects on oral microbiota diversity and normal tissues, predominately arising from the poor biofilm-targeting property of the agents. Methods: To address this concern, we herein report dual-sensitive antibacterial peptide nanoparticles pHly-1 NPs upon acid and lipid-binding for treatment of dental caries. Amino acid substitutions were performed to design the peptide pHly-1. The potential, morphology and secondary structure of pHly-1 were...

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Dual-sensitive antibacterial peptide nanoparticles prevent dental caries

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