An enhanced silver nanocluster system for cytochrome c detection and natural drug screening targeted for cytochrome c

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成果类型：

期刊论文

作者：

Qin, Yan;Daniyal, Muhammad;Wang, WenMiao;Jian, YuQing;Yang, Wei;...

通讯作者：

Wang, Wei;Liu, Bin

作者机构：

[Qin, Yan; Wang, Wei; Qiu, YiXing; Jian, YuQing; Daniyal, Muhammad] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM, Changsha 410208, Hunan, Peoples R China.

[Qin, Yan; Wang, Wei; Qiu, YiXing; Jian, YuQing; Daniyal, Muhammad] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.

[Liu, Bin; Wang, WenMiao; Tong, ChunYi] Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.

[Yang, Wei] Hunan Womens Univ, Coll Foreign Languages, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Wang, Wei; Liu, Bin] H

Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.

Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

Cytochrome c;DNA-templated silver nanoclusters (DNA-AgNCs);Natural compounds;Drugs screening

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2019

卷：

291

页码：

485-492

DOI：

10.1016/j.snb.2018.12.103

基金类别：

National Natural Science Foundation of the People's Republic of ChinaNational Natural Science Foundation of China (NSFC) [81673579, 81874369]; State Administration of TCM [ZYBZH-Y-HUN-23]; Key Research and Development Programs of Hunan Science and Technology Department [2018SK2113, 2018SK2119, 2018WK2081]; Hunan Provincial Science and Technology Department [HHS2017zy03]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

A label-free and turn-off fluorescence method for detecting cytochrome c (Cyt c) was developed using enhanced DNA-templated silver nanoclusters ([email protected] 80) as a novel fluorescence-enhancing nanoprobe. Cyt c-induced electron transfer between Cyt c and DNA-AgNCs results in a significant fluorescence quenching effect of DNA-AgNCs. The coated tween 80 around DNA-AgNCs particles significantly causes fluorescence signal enhancement in the solution. Meanwhile, the efficiency of fluorescence quenching by Cyt c increases substantially by addi...

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An enhanced silver nanocluster system for cytochrome c detection and natural drug screening targeted for cytochrome c

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