Muscone Ameliorates LPS-Induced Depressive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice

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成果类型：

期刊论文

作者：

He, Ming-Chao;Shi, Zhe;Qin, Meng;Sha, Nan-Nan;Li, Yue;...

通讯作者：

Wang, Yong-Jun;Zhang, Yan;Yuan, Ti-Fei

作者机构：

[Wang, Yong-Jun; Sha, Nan-Nan; Shu, Bing; He, Ming-Chao; Sun, Yue-Li; Wang, YJ; Zhang, Yan; Li, Yue] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Spine Dis Res Inst, Room 908,Bldg 12,725 South Wanping Rd, Shanghai 200032, Peoples R China.

[Wang, Yong-Jun; Shu, Bing; He, Ming-Chao; Sun, Yue-Li; Li, Yue; Zhang, Yan] Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China.

[Yuan, Ti-Fei; Shi, Zhe] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 201108, Peoples R China.

[Liao, Duan-Fang; Shi, Zhe] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Peoples R China.

[Qin, Meng] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China.

通讯机构：

[Wang, YJ; Zhang, Y; Yuan, Ti-Fei] S

Shanghai Univ Tradit Chinese Med, Longhua Hosp, Spine Dis Res Inst, Room 908,Bldg 12,725 South Wanping Rd, Shanghai 200032, Peoples R China.

Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 201108, Peoples R China.

语种：

英文

关键词：

Depression;Microglia;Muscone;Neuroinflammation;Renin-Angiotensin System

期刊：

American Journal of Chinese Medicine

ISSN：

0192-415X

年：

2020

卷：

期：

页码：

559-577

DOI：

10.1142/S0192415X20500287

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81774329, 81804115]; Essential Drug Research and Development [2019ZX09201004003-032]; National Key RD Program [2018YFC1704302]; Program for Innovative Research Team from Ministry of Science and Technology of China [2015RA4002]; Hundred Talents Program from Shanghai Municipal Commission of Health and Family Planning [2018BR03]; Program of Shanghai Academic Research Leader [19XD1423800]; Innovative Research Team of Ministry of Education of China [IRT1270]; Sanming Project of Medicine in Shenzhen [SZSM201808072]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Depression is partially caused by inflammation in the central nervous system. Early study demonstrated that musk, glandular secretion from male musk deer, exerted an antidepressant-like effect. The aim of this study was to investigate if muscone, a bioactive ingredient in musk, could ameliorate neuroinflammation and depressive-like behaviors as well as explore the potential action mechanism. Mice were intraperitoneally (i.p.) injected with muscone for 2 weeks prior to administration of lipopolysaccharides (LPS, 1mg/kg, i.p.). Pre-treatment with...

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Muscone Ameliorates LPS-Induced Depressive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice

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