Muscone Ameliorates LPS-Induced Depressive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice

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成果类型：

期刊论文

作者：

He, Ming-Chao;Shi, Zhe;Qin, Meng;Sha, Nan-Nan;Li, Yue;...

通讯作者：

Wang, Yong-Jun;Zhang, Y;Yuan, TF

作者机构：

[Wang, Yong-Jun; Sha, Nan-Nan; Shu, Bing; He, Ming-Chao; Sun, Yue-Li; Li, Yue; Zhang, Yan; Wang, YJ] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Spine Dis Res Inst, Room 908,Bldg 12,725 South Wanping Rd, Shanghai 200032, Peoples R China.

[Wang, Yong-Jun; Shu, Bing; He, Ming-Chao; Sun, Yue-Li; Li, Yue; Zhang, Yan] Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China.

[Yuan, Ti-Fei; Shi, Zhe] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 201108, Peoples R China.

[Liao, Duan-Fang; Shi, Zhe] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Peoples R China.

[Qin, Meng] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China.

通讯机构：

[Yuan, TF ; Zhang, Y ; Wang, YJ] S

Shanghai Univ Tradit Chinese Med, Longhua Hosp, Spine Dis Res Inst, Room 908,Bldg 12,725 South Wanping Rd, Shanghai 200032, Peoples R China.

Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 201108, Peoples R China.

语种：

英文

关键词：

Depression;Muscone;Microglia;Neuroinflammation;Renin-Angiotensin System

期刊：

AMERICAN JOURNAL OF CHINESE MEDICINE

ISSN：

0192-415X

年：

2020

卷：

期：

页码：

559-577

DOI：

10.1142/S0192415X20500287

基金类别：

National Natural Science Foundation of China#&#&#81774329#&#&#81804115 Essential Drug Research and Development#&#&#2019ZX09201004-003-032 National Key R&D Program#&#&#2018YFC1704302 Program for Innovative Research Team#&#&#2015RA4002 Ministry of Science and Technology of China, Hundred Talents Program from Shanghai Municipal Commission of Health and Family Planning#&#&#2018BR03 Program of Shanghai Academic Research Leader#&#&#19XD1423800 Innovative Research Team of Ministry of Education of China#&#&#IRT1270 Sanming Project of Medicine in Shenzhen#&#&#SZSM201808072

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Depression is partially caused by inflammation in the central nervous system. Early study demonstrated that musk, glandular secretion from male musk deer, exerted an antidepressant-like effect. The aim of this study was to investigate if muscone, a bioactive ingredient in musk, could ameliorate neuroinflammation and depressive-like behaviors as well as explore the potential action mechanism. Mice were intraperitoneally (i.p.) injected with muscone for 2 weeks prior to administration of lipopolysaccharides (LPS, 1[Formula: see text]mg/kg, i.p.). Pre-treatment with muscone reversed the LPS-indu...

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Muscone Ameliorates LPS-Induced Depressive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice

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