Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Hong;Zhang, Er-Bing;Yi, Ou-Yang;Wu, Han;Deng, Guiming;...

通讯作者：

Wen-Liang Liu<&wdkj&>Jian-Ye Yan<&wdkj&>Xiong Cai

作者机构：

[Cai, Xiong; Wu, Han; Yi, Ou-Yang; Yan, Jian-Ye; Deng, Guiming; Zhang, Er-Bing; Huang, Hong] Hunan Univ Chinese Med, Hosp 1, Dept Rheumatol, Changsha 410007, Hunan, Peoples R China.

[Cai, Xiong; Wu, Han; Yi, Ou-Yang; Yan, Jian-Ye; Deng, Guiming; Zhang, Er-Bing; Huang, Hong] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha 410007, Hunan, Peoples R China.

[Liu, Wen-Liang; Zhang, Er-Bing] Shenzhen Inst Drug Control, Shenzhen 518057, Guangdong, Peoples R China.

[Huang, Yu-Ming] Hunan Zhengqing Pharmaceut Grp Co Ltd, Huaihua 418000, Hunan, Peoples R China.

通讯机构：

[Wen-Liang Liu] S

[Jian-Ye Yan; Xiong Cai] D

Shenzhen Institute for Drug Control, Shenzhen, China<&wdkj&>Department of Rheumatology of the First Hospital and Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Department of Rheumatology of the First Hospital and Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Pharmacokinetics;Safety profile;Sex differences;Sinomenine hydrochloride;Tissue distribution;UPLC-MS/MS

期刊：

Archives of Toxicology

ISSN：

0340-5761

年：

2022

卷：

期：

页码：

3245-3255

DOI：

10.1007/s00204-022-03368-1

基金类别：

National Natural Science Foundation of China General Program [8227153595]; Science and Technology Innovation Program of Hunan Province [2020SK1020, XKJ[2021]43-2021RC4035]; Hunan Furong Distinguished Scholar Program [XJT[2020]58]; Hunan 121 Training Project for Innovative Talents [XRSH[2019]192]; Chinese Academy of Engineering Academician Liang Liu's Workstation of Hunan University of Chinese Medicine (HNUCM) [XKXT[2020]34]; National First-class Disciple Construction Project of Chinese Medicine of HNUCM [XXKZ[2018]3]

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

摘要：

Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum (Thunb.) Rehd. et Wils which exhibits significant analgesic, anti-inflammatory, and immunosuppressive effects. Sinomenine hydrochloride (SH) preparations, classified as natural disease-modifying antirheumatic drugs, are currently available for the treatment of rheumatoid arthritis and other rheumatic diseases. Our toxicity evaluation demonstrated that the median lethal dose of SH in female Sprague-Dawley (SD) rats was over 11 times greater than that in male SD rats, revealing striking sex-linked diff...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问