Smart Self-Assembled Peptide-based Hydrogels: Mechanism, Design and Biomedical Applications

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成果类型：

期刊论文

作者：

Ma, Tao;Yu, Yi;Gao, Yijun;Jiang, Shanshan;Ge, Wenhui;...

通讯作者：

Xie, XY;Guan, GP

作者机构：

[Jiang, Shanshan; Zeng, Yiyu; Xie, Xiaoyan; Yu, Yi; Wang, Xinying; Gao, Yijun; Ma, Tao; Ge, Wenhui] Cent South Univ, Xiangya Hosp 2, Dept Stomatol, Changsha 410011, Peoples R China.

[Li, Shuangjiang] Hunan Univ Chinese Med, Changsha Stomatol Hosp, Dept Stomatol, Changsha 410011, Peoples R China.

[Guan, Gaopeng] Cent South Univ, Xiangya Hosp 3, Dept Endocrinol, Changsha 410011, Peoples R China.

[Xie, Xiaoyan; Xie, XY] Cent South Univ, Xiangya Hosp 2, Changsha 410011, Peoples R China.

[Guan, Gaopeng; Guan, GP] Cent South Univ, Xiangya Hosp 3, Changsha 410011, Peoples R China.

通讯机构：

[Guan, GP ; Xie, XY ] C

Cent South Univ, Xiangya Hosp 2, Changsha 410011, Peoples R China.

Cent South Univ, Xiangya Hosp 3, Changsha 410011, Peoples R China.

语种：

英文

关键词：

biomedical engineering;regenerative medicine;self-assembled peptide hydrogel;smart biomaterials;stimuli-responsive hydrogel

期刊：

Colloids and Surfaces B: Biointerfaces

ISSN：

0927-7765

年：

2025

卷：

253

页码：

114704

DOI：

10.1016/j.colsurfb.2025.114704

基金类别：

sources This study was supported by the Health Commission of Hunan Province (Project No. W20243139 and No. 20200057 ), and the "co-PI" project from The Third Xiangya hospital of Central South University (Project No. 202409 ). CRediT authorship contribution statement Xinying Wang: Methodology. Shuangjiang Li: Formal analysis. Wenhui Ge: Formal analysis. Yiyu Zeng: Methodology. Tao Ma: Writing – original draft. Gaopeng Guan: Project administration. Yijun Gao: Conceptualization. Shanshan Jiang: Formal analysis. Yi Yu: Writing – review & editing, Visualization. Xiaoyan Xie: Visualization, acquisition.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Peptide hydrogels have gained widespread attention in biomedical engineering due to their unique ability to mimic the cellular microenvironment in vivo. Stimulus-responsive self-assembled (SAP) hydrogels can undergo conformational changes in response to changes in the external environment, prompting a sol-gel transition. Their inherent biodegradability, excellent surface activity and biocompatibility make them ideal candidates for a wide range of biomedical applications, and these SAP hydrogels can be widely used in the fields of tissue engineering, cell and drug delivery, wound healing and me...

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