Exploring the Mechanism of Zhibai Dihuang Decoction in the Treatment of Ureaplasma Urealyticum-Induced Orchitis Based on Integrated Pharmacology

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成果类型：

期刊论文

作者：

Bin, Dong-hua;Zhang, Shi-ying;Zhan, Min;Li, Ling;Li, Ying-qiu;...

作者机构：

[Zhou, Qing; Zhan, Min; Bin, Dong-hua; Zhou, Xing] Hunan Univ Chinese Med, Surg Tradit Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.

[Zhang, Shi-ying; Li, Ling; Bin, Dong-hua] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Peoples R China.

[Zhang, Shi-ying] Shenzhen Luohu Peoples Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.

[Zhang, Shi-ying] Shenzhen Univ, Dept Tradit Chinese Med, Affiliated Hosp 3, Shenzhen, Peoples R China.

[Lu, Fang-guo; Li, Ying-qiu] Hunan Univ Chinese Med, Med Sch, Changsha, Peoples R China.

语种：

英文

关键词：

Zhibai Dihuang Decoction;Ureaplasma urealyticum;Orchitis;Integrated pharmacological;bioinformatics;Chinese medicine;Herb medicine

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2021

卷：

页码：

602543

DOI：

10.3389/fphar.2021.602543

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973863, 81603634, 81774324]; Science Research Program of Hunan Education Department [19B418]; Scientific research project of Hunan Health Committee [20200745]

机构署名：

本校为第一机构

院系归属：

医学院

中医学院

第一中医临床学院

中西医结合学院

摘要：

Background: Ureaplasma urealyticum (UU) infection is the most common cause of male infertility. Zhibai Dihuang Decoction (ZBDHD) can improve the rate of forwarding motility sperm, sperm deformity rate, seminal plasma zinc and refined berry sugar levels. Methods: The potential targets of ZBDHD are obtained from The Encyclopedia of Traditional Chinese Medicine (ETCM). Orchitis-related targets were collected from the Genecards and OMIM databases. The Cytoscape and the Database for Annotation, Visualization and Integrated Discovery (DAVID) were utilized to construct and analyzed the networks. Fina...

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Exploring the Mechanism of Zhibai Dihuang Decoction in the Treatment of Ureaplasma Urealyticum-Induced Orchitis Based on Integrated Pharmacology

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