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Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma

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成果类型:
期刊论文
作者:
Liu, Bo;Liu, Jingping;Liao, Yuxiang;Jin, Chen;Zhang, Zhiping;...
通讯作者:
Cheng, Quan
作者机构:
[Liu, Bo; Liu, Jingping; Liao, Yuxiang; Jin, Chen; Cheng, Quan; Zhao, Jie; Zhang, Zhiping] Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China.
[Liu, Kun; Huang, Hao] Hosp Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Dept Neurosurg, Changsha, Hunan, Peoples R China.
[Cao, Hui] Hosp Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
[Cheng, Quan] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China.
通讯机构:
[Cheng, Quan] C
Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China.
Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
Drug resistance;Glioblastoma;Prognosis;Radiotherapy
期刊:
Medical Science Monitor
ISSN:
1643-3750
年:
2019
卷:
25
页码:
3624-3635
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703622]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M633002]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ3838]
机构署名:
本校为其他机构
摘要:
Background: The survival and therapeutic outcome vary greatly among glioblastoma (GBM) patients. Treatment resistance, including resistance to temozolomide (TMZ) and radiotherapy, is a great obstacle for these therapies. In this study, we aimed to evaluate the predictive value of SEC61G on survival and therapeutic response in GBM patients.Material/Methods: Survival analyses were performed to assess the correlation between SEC61G expression and survival of GBM patients from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA...

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