期刊论文

中文

中国动脉硬化杂志

1007-3949

2016

24

1

39-43

湖南省中医药科研项目（201516）；

本校为第一机构

目的 观察心痛泰对动脉粥样硬化兔血脂、载脂蛋白A、B及主动脉氧化型低密度脂蛋白(ox-LDL)和白细胞介素1β(IL-13)的影响.方法 120只清洁级日本大耳白兔随机分为六组:空白组、模型组、心痛泰高剂量、中剂量和低剂量组、瑞舒伐他汀组,采用高脂喂养加免疫损伤造模,造模同时予以相应药物灌胃.60天后,采血测定血脂与载脂蛋白.取胸主动脉用免疫组织化学法测定ox-LDL、IL-1β.结果 与模型组相比,心痛泰中剂量、高剂量组和瑞舒伐他汀组总胆固醇、甘油三酯、低密度脂蛋白、载脂蛋白B明显降低(P＜0.01或P＜0.05),载脂蛋白A和高密度脂蛋白明显升高(P＜0.01或P＜0.05),主动脉ox-LDL、IL-1β明显降低(P＜0.0...

Aim To study the effects of Xin Tong-tai （XTY） on levels of serum lipid and apolipoprotein A, B and aortic oxidized low density lipoprotein （ox-LDL） and interleukin-1β （IL-1β） in rabbits with hyperlipidemia. Methods 120 clean grade healthy Japanese rabbits were randomly divided into control group, model group, low-dose XTT group, middle-dose XTI＂ group, high-dose XTT group and rosuvastatin group. All rabbits were sacrificed by high-fat diet and immunologic injury. The drug intervention groups were treated with the corresponding drugs f...