期刊论文

Xin Tong-tai reduces inflammation of atherosclerosis by lowering the levels of Lp-PLA2,IL-6,hs-CRP and LOX-1 in rabbits

中文

中国动脉硬化杂志

1007-3949

2017

25

8

796-799

10.3969/j.issn.1007-3949.2017.08.007

湖南省中医药科研项目（201516）；

本校为第一机构

目的 研究心痛泰对动脉粥样硬化兔血清脂蛋白相关磷脂酶A2(Lp-PLA2)、白细胞介素6(IL-6)以及主动脉组织高敏C反应蛋白(hs-CRP)和血凝素样氧化型低密度脂蛋白受体1(LOX-1)的影响.方法 120只日本大耳白兔随机分为空白组、模型组、心痛泰低剂量组、中剂量组、高剂量组和瑞舒伐他汀组.采用前瞻性研究,造模的同时予以相应药物灌胃.60天后采血,测定血清Lp-PLA2和IL-6水平;免疫组织化学法检测胸主动脉hs-CRP和LOX-1含量.结果 心痛泰低剂量组、中剂量组和高剂量组血清Lp-PLA2和IL-6水平比模型组低(P＜0.01);与心痛泰低剂量组比较,心痛泰中剂量组和高剂量组、瑞舒伐他汀组血清Lp-PLA2和IL-6水平降低(P＜0...

Aim To study the effects of Xin Tong-tai（ XTT） on serum lipoprotein-associated phospholipase A2（ Lp-PLA2） and interleukin 6（ IL-6）,and aortic tissue high-sensitivity C-reactive protein（ hs-CRP） and lectin-like oxidized low density lipoprotein receptor-1（ LOX-1） in atherosclerotic rabbits. Methods A total of 120 healthy Japanese rabbits were randomly divided into control group,model group,low-dose XTT group,middle-dose XTT group,high-dose XTT group and rosuvastatin group. In this prospective study,the drug intervention groups were trea...