期刊论文

The roles of autophagy and its research progress in the prevention of cardiovascular aging by natural pharmaceutical active ingredients

中文

中国动脉硬化杂志

1007-3949

2020

28

2

175-180

10.3969/j.issn.1007-3949.2020.02.016

国家自然科学基金项目(81773736) 湖南中医药大学研究生创新课题项目(2018CX02).

本校为第一机构

心血管系统维持着机体正常的生命活动,心血管系统衰老可引发高血压、动脉粥样硬化、心力衰竭、心肌梗死等疾病。自噬是一种溶酶体依赖性降解途径,其水平随着年龄增加而逐渐降低,一方面提高机体自噬可延缓细胞和组织衰老,另一方面自噬水平的过度激活可诱导细胞自噬性死亡、加速衰老。某些天然药物活性成分能调节自噬,并改善心血管系统衰老。它们可能是通过调节细胞自噬发挥对心血管系统衰老的保护作用。因此,文章就自噬在天然药物活性成分延缓心血管系统衰老中的作用及研究进展进行综述。

The cardiovascular system maintains normal life activities of the body,and the cardiovascular system aging will cause diseases such as hypertension,atherosclerosis,heart failure,myocardial infarction.Autophagy is a lysosomal-dependent degradation pathway.The level of autophagy gradually decreases with age.On one hand increasing autophagy can delay cells and tissues aging.On the other hand,excessive activation of autophagy levels will induce autophagic death and accelerate aging.Some natural pharmaceutical active ingredients regulate autophagy and ameliorate cardiovascular system aging.They may...