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Suppressed Immune-Related Profile Rescues Abortion-Prone Fetuses: A Novel Insight Into the CBA/J x DBA/2J Mouse Model

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成果类型:
期刊论文
作者:
Yi, Xiaochun;Zhang, Jie;Liu, Huixiang;Yi, Tianxia;Ou, Yuhua;...
通讯作者:
Chen, Hui;Zhang, Jianping
作者机构:
[Yi, Xiaochun; Chen, Hui; Liu, Huixiang; Liu, Meilan; Zhang, Jianping; Chen, H; Zhang, JP; Zhu, Liqiong; Ou, Yuhua] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou 510000, Guangdong, Peoples R China.
[Zhang, Jie] Guangdong Women & Children Hosp, Dept Rehabil Med, Guangzhou, Guangdong, Peoples R China.
[Yi, Tianxia] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
通讯机构:
[Chen, H; Zhang, JP] S
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou 510000, Guangdong, Peoples R China.
语种:
英文
关键词:
RNA-seq;RSA;abortion-prone model;immunosuppression
期刊:
Reproductive Sciences
ISSN:
1933-7191
年:
2019
卷:
26
期:
11
页码:
1485-1492
机构署名:
本校为其他机构
摘要:
The adverse clinical result and poor treatment outcome in recurrent spontaneous abortion (RSA) make it necessary to understand the pathogenic mechanism. The mating combination CBA/J x DBA/2 has been widely used as an abortion-prone model compared to DBA/2-mated CBA/J mice. Here, we used RNA-seq to get a comprehensive catalogue of genes differentially expressed between survival placenta in abortion-prone model and control. Five hundred twenty-four differentially expressed genes were obtained followed by clustering analysis, Gene Ontology analysis, and pathway analysis. We paid more attention to...

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