Study on the Inhibition of PLD on IAV-induced Pulmonary Macrophage Based on Autophagy and Apoptosis

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成果类型：

期刊论文

作者：

Li, Ling;Ning, Yi;Wei, Ke;Hu, Jue;Wu, Tao;...

通讯作者：

Lu, Fang-Guo;He, Qing-Hu

作者机构：

[Li, Ling] Hunan Univ Chinese Med, Dept Expt Ctr Med Basic Teaching, Coll Tradit Chinese Med, Changsha, Hunan, Peoples R China.

[Lu, Fang-Guo; Ning, Yi; Wei, Ke] Hunan Univ Chinese Med, Dept Microbiol, Med Sch, Xueshi Rd 300, Changsha 410208, Hunan, Peoples R China.

[Wu, Tao; Zhao, Cheng; Hu, Jue] Hunan Univ Chinese Med, Grad Sch, Dept Postgrad, Changsha, Hunan, Peoples R China.

[He, Qing-Hu] Hunan Univ Chinese Med, Lab Integrated Chinese & Western Med, Coll Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Lu, Fang-Guo; He, Qing-Hu] H

Hunan Univ Chinese Med, Dept Microbiol, Med Sch, Xueshi Rd 300, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Lab Integrated Chinese & Western Med, Coll Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;autophagy;influenza virus;macrophages;platycodin D

期刊：

Pharmacognosy Magazine

ISSN：

0973-1296

年：

2020

卷：

期：

页码：

132-139

DOI：

10.4103/pm.pm_207_19

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973670, 81503445, 81774126, 81703919, 81803964]; Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2016JJ2095]; Education Department of Hunan Province, the innovation platform of open fund project [17K067]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

中医学院

中西医结合学院

研究生院

摘要：

Background: Platycodin D (PLD) comes from the main triterpenoid saponins in the dry roots of Platycodon grandiflorum, which has been used in traditional Chinese medicine in the treatment of respiratory disease. This study aimed to evaluate the therapeutic effects of PLD on mouse alveolar macrophages induced by influenza A virus (IAV) in vitro and to investigate the PLD of its action. Materials and Methods: Raw264.7 mouse alveolar macrophages were grown in culture and the Cell Counting Kit-8 assay determined cell viability. Cells were treated for 24 h with increasing doses of PLD (0, 5, 10, 20,...

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Study on the Inhibition of PLD on IAV-induced Pulmonary Macrophage Based on Autophagy and Apoptosis

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