Endothelial progenitor cell (EPCs)-derived exosomal miR-30d-5p inhibits the inflammatory response of high glucose-impaired fibroblasts by affecting the M1/M2 polarization of macrophages

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成果类型：

期刊论文

作者：

Xiong, Wu;Tan, Mei-xin;Chen, Zi-lin;Liu, Yu;Liu, Yang;...

作者机构：

[Xiong, Wu] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Burns & Plast Surg, Changsha, Peoples R China.

[Chen, Zi-lin; Wang, Xiao-qin; Yang, Ya; Tan, Mei-xin; Tan, Pei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.

[Liu, Yu] Inner Mongolia Med Univ, Coll Tradit Chinese Med, Hohhot, Peoples R China.

[Liu, Yang] Cent South Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha, Peoples R China.

[Zou, Xiao-ling] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinolog, Changsha, Peoples R China.

语种：

英文

关键词：

diabetes mellitus;miR-30d-5p;high-glucose impaired HKF;EPCs exosomes

期刊：

Revista Romana de Medicina de Laborator

ISSN：

1841-6624

年：

2022

卷：

期：

页码：

435-451

DOI：

10.2478/rrlm-2022-0032

基金类别：

National Natural Science Foundation of China Youth Science Fund Project [81904217]

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

Background: Diabetes is a common chronic disease which has caused a great burden on families and society. The treatment of diabetes has always been a hotspot. This study aimed to explore the effect and mechanism of miR-30d-5pon inflammation of high glucose-impaired human keloid fibroblasts (HKF). Methods: Differently-expressed miRNAs were predicted by bioinformatics methods. Exosomes were observed by transmission electron microscope. Exosome particle sizes were measured by NanoSight. Western Blot was used to detect the expression of CD81, CD63, CD9, and Calnexin. QRT-PCR was used to detect the...

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Endothelial progenitor cell (EPCs)-derived exosomal miR-30d-5p inhibits the inflammatory response of high glucose-impaired fibroblasts by affecting the M1/M2 polarization of macrophages

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