Lactase bacteria in intestinal mucosa are associated with diarrhea caused by high-fat and high-protein diet

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成果类型：

期刊论文

作者：

Zhou, Kang;Peng, Maijiao;Deng, Na;Tan, Zhoujin;Xiao, Nenqun

通讯作者：

Nenqun Xiao

作者机构：

[Xiao, Nenqun; Zhou, Kang; Peng, Maijiao] Hunan Univ Chinese Med, Coll Pharm, Changsha, Hunan, Peoples R China.

[Deng, Na] Hunan Univ Chinese Med, Coll Chinese Med, Changsha, Hunan, Peoples R China.

[Tan, Zhoujin] Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha, Hunan, Peoples R China.

[Tan, Zhoujin] Hunan Univ Chinese Med, Coll Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Xiao, Nenqun] C

College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China.

语种：

英文

关键词：

High-fat and high-protein diet;Gene diversity;Lactase bacteria;Diarrhea;Intestinal mucosa

期刊：

BMC Microbiology

ISSN：

1471-2180

年：

2022

卷：

期：

页码：

1-10

DOI：

10.1186/s12866-022-02647-2

基金类别：

This work was supported by grants from the Natural Science Foundation of Hunan Province (No: 2020JJ4468) and Key Discipline of Biological Engineering of Hunan University of Chinese Medicine ([2018] No.3). The funding bodies played no role in design of the study, analysis and interpretation of the data.

机构署名：

本校为第一机构

院系归属：

医学院

药学院

摘要：

Background: Excessive fat and protein in food can cause diarrhea by disturbing the intestinal microecology. Lactase is a functional enzyme strongly associated with diarrhea, while lactase bacteria in the intestine are an important source of microbial lactase. Therefore, we reconnoiter the relationship between diarrhea induced by a high-fat and high-protein diet (HFHPD) and intestinal mucosal lactase bacteria from the perspective of functional genes. Result: Operational Taxonomic Units (OTUs) were 23 and 31 in the normal group (NM) and model gro...

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Lactase bacteria in intestinal mucosa are associated with diarrhea caused by high-fat and high-protein diet

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