Epigallocatechin-3-Gallate Attenuates Impairment of Learning and Memory in Chronic Unpredictable Mild Stress-Treated Rats by Restoring Hippocampal Autophagic Flux

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成果类型：

期刊论文

作者：

Gu, Hong-Feng;Nie, Ya-Xiong;Tong, Qiao-Zhen;Tang, Ya-Ling;Zeng, Yang;...

通讯作者：

Liao, Duan-Fang

作者机构：

[Gu, Hong-Feng; Tang, Ya-Ling] Univ South China, Dept Physiol, Hengyang, Peoples R China.

[Gu, Hong-Feng; Tang, Ya-Ling] Univ South China, Inst Neurosci, Hengyang, Peoples R China.

[Gu, Hong-Feng; Zheng, Xi-Long; Tong, Qiao-Zhen] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

[Jing, Kai-Quan; Nie, Ya-Xiong; Zeng, Yang] Univ South China, Dept Neurol, Affiliated Hosp 1, Hengyang, Peoples R China.

[Zheng, Xi-Long; Liao, Duan-Fang] Univ Calgary, Fac Med, Smooth Muscle Res Grp, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, Calgary, AB, Canada.

通讯机构：

[Liao, Duan-Fang] U

Univ Calgary, Fac Med, Smooth Muscle Res Grp, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, Calgary, AB, Canada.

语种：

英文

关键词：

Cognitive impairment;Autophagic cell death;Learning and memory;Memory;Alzheimer's disease;Hippocampus;Neurons;Psychological stress

期刊：

PLoS ONE

ISSN：

1932-6203

年：

2014

卷：

期：

页码：

e112683-

DOI：

10.1371/journal.pone.0112683

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170278]; Nature Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [08JJ3036]; construct program of the key discipline in hunan province, China (Basic Medicine Sciences in University of South China); Foundation of Hunan Educational Committee [09C835]

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本校为其他机构

院系归属：

药学院

摘要：

Epigallocatechin gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the impairment in learning and memory. Autophagy is a cellular process that protects neurons from stressful conditions. The present study was designed to investigate whether EGCG can rescue chronic unpredictable mild stress (CUMS)-induced cognitive impairment in rats and whether its protective effect involves improvement of autophagic flux. As expected, our results showed that CUMS significantly impaired memory performance and inhibited autophagic flux...

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Epigallocatechin-3-Gallate Attenuates Impairment of Learning and Memory in Chronic Unpredictable Mild Stress-Treated Rats by Restoring Hippocampal Autophagic Flux

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