Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress

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成果类型：

期刊论文

作者：

Yang, Yunrong;Liu, Min;Zhao, Tianjiao;Chen, Qiaohui;Yang, Yuqi;...

作者机构：

[Huang, Qiong; Yang, Yuqi; Zhang, Jinping; Yang, Yunrong] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China.

[Huang, Qiong; Yang, Yuqi; Zhang, Jinping; Yang, Yunrong] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.

[Liu, Min; Chen, Qiaohui; Wang, Shuya; Zhao, Tianjiao; Ai, Kelong] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Peoples R China.

[Liu, Min; Chen, Qiaohui; Wang, Shuya; Zhao, Tianjiao; Ai, Kelong] Cent South Univ, Xiangya Sch Pharmaceut Sci, Hunan Prov Key Lab Cardiovasc Res, Changsha, Peoples R China.

[Sun, Kewei; Deng, Guiming] Hunan Univ Chinese Med, Dept Infect & Liver Dis, Hosp 1, Changsha, Peoples R China.

语种：

英文

关键词：

epigallocatechin-3-gallate Mo nanoparticles;reactive oxygen species;acetaminophen;drug-induced liver injury;anti-inflammatory;endoplasmic reticulum stress

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2022

卷：

页码：

4134

DOI：

10.3389/fphar.2022.1039558

基金类别：

National Natural Science Foundation of China [81974508, 21974134, 81973833]; Hunan Provincial Natural Science Foundation of China [2021JJ31066, 2022JJ70028, 2021JJ30526]; Hunan Science Fund for Distinguished Young Scholar of China [2021JJ10067]; Innovation-Driven Project of Central South University [202045005]; Key Research Project of Ningxia Hui Autonomous Region in 2021 of China (Major Project) [2021BEG01001]; Key Program of Ningxia Hui Autonomous Region Natural Science Foundation of China [2022JJ21059]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses. However, traditional treatments were limited by low efficacy and serious side effects due to the special liver structure. Here, we developed a molybdenum (Mo)-based nanoparticles, EGM NPs, after overall consideration of the pathophysiology of DILI and the advantages of nanodrugs. It demonstrated that EGM NPs treated acetaminophen (APAP)-induced DILI by scavenging ROS and inhibiting inflammation. EGM NPs effectively scavenged various ROS and r...

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Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress

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