期刊论文

中文

临床肝胆病杂志

1001-5256

2012

28

10

752-755

10.3969/j.issn.1001-5256.2012.10.10t

国家十一五科技重大专项（No.2008ZX10005-007）；

本校为第一机构

目的研究在HBV感染相关肝衰竭抗病毒治疗过程中,早期快速病毒学应答对治疗转归的影响。方法选择本院2007年6月至2010年12月住院治疗的HBV感染相关肝衰竭患者152例,在内科综合治疗基础上分别予拉米夫定（LAM）或恩替卡韦（ETV）抗病毒治疗。根据抗病毒治疗第4周时患者HBV DNA是否转阴,将患者分为HBV DNA阴性组和HBV DNA阳性组,比较两组治疗基线情况、治疗第4周时TBil、凝血酶原活动度（PTA）、Alb、MELD评分及治疗终点时两组临床转归,对影响治疗转归的所有因素进行多元Logistic逐步回归分析。结果在治疗第4周时,HBV DNA阴性组TBil水平较HBV DNA阳性组明显降低,两组差异有统计学意义（P=0.000）;H...

Objective To investigate the impact of early virological response to antiviral treatment on the outcomes of hepatitis B - associat- ed liver failure. Methods One - hundred - and - fifty - two patients with hepatitis B - associated liver failure treated in our hospital from June 2007 to December 2010 were retrospectively enrolled in the study. In addition to standard traditional Chinese medicine therapy （ inclu- ding conventional Hugan soup, JiangMei hepatoprotective treatment, and artificial liver treatment）, all patients were given lamivudin...