期刊论文

Clinical effect of integrated traditional Chinese and Western medicine therapy in patients with hepatitis B virus-related acute-on-chronic liver failure complicated by hepatic encephalopathy

中文

临床肝胆病杂志

1001-5256

2018

34

4

795-800

10.3969/j.issn.1001-5256.2018.04.020

2012ZX10005-005:国家科技重大专项 2018ZX10725506-002:国家科技重大专项 JDZX2015187:国家中医药局专项

本校为其他机构

目的 探讨中西医结合治疗HBV相关慢加急性肝衰竭(ACLF)合并肝性脑病(HE)患者8周病死率情况,分析影响其预后的独立危险因素.方法 选取2012年1月-2015年2月18家医院收治的HBV-ACLF患者,采用随机对照设计分为试验组和对照组,分别给予中西医结合治疗和单纯西医综合治疗,纳入所有0周合并HE的患者125例.观察2组8周病死率情况.计量资料2组间比较采用t检验或Mann-Whitney U检验,计数资料2组间比较采用x2检验,生存分析采用Kaplan-Meier方法及log-rank检验,危险因素分析采用Cox比例风险回归模型.结果 试验组及对照组8周病死率分别为27.5％、50.0％(x2=5.630,P=0.018),8周内中位生存时间分别为41.2d、28.4 ...

Objective To investigate the 8-week mortality rate of patients with hepatitis B virus（HBV）-related acute-on-chronic liver failure（ACLF） complicated by hepatic encephalopathy（HE） treated with integrated traditional Chinese and Western medicine therapy,as well as independent prognostic factors.Methods A total of 125 HBV-ACLF patients with HE who were admitted to 18 hospitals from January 2012 to February 2015 were enrolled and divided into trial group and control group using a randomized controlled design.The patients in the trial group wer...