期刊论文

Expression features and clinical significance of the microRNA-888 gene family in hepatocellular carcinoma

中文

临床肝胆病杂志

1001-5256

2019

35

1

119-122

10.3969/j.issn.1001-5256.2019.01.022

本校为第一机构

目的初步探讨microRNA-888（miRNA-888）基因家族成员在肝细胞癌中的表达特征及其意义。方法选取湖南中医药大学第一附属医院在2012年1月-2017年12月病理确诊为肝细胞癌的患者72例,另收集72例健康自愿者的肝组织作为正常对照组。运用实时定量PCR和原位杂交分析肝癌组织中miRNA-888家族中miRNA-888、miRNA-891a、miRNA-891b、miRNA-892a和miRNA-892b的表达情况,初步探讨miRNA-888、miRNA-891b和miRNA-892a的表达与肝癌临床病理特征的关系。计量资料2组间比较采用t检验;计数资料组间比较采用χ2检验。结果 miRNA-888、miRNA-891b、miRNA-892a在肝癌组织中的表达明显高于正常肝组织（2. 53±0. 75 ...

Objective To investigate the expression features and clinical significance of the microRNA-888( miRNA-888) gene family members in hepatocellular carcinoma( HCC). Methods A total of 72 patients with pathologically confirmed HCC who were treated in The First Affiliated Hospital of Hunan University of Chinese Medicine from January 2012 to December 2017 were enrolled,and 72 liver tissue samples collected from healthy volunteers were enrolled as normal control group. Quantitative real-time PCR and in situ hybridization were used to measure the expre...