Cigarette Smoke Extract and Lipopolysaccharide Induce Pyroptosis in Pulmonary Microvascular Endothelial Cells of Rats

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成果类型：

期刊论文

作者：

Wang, Q.;Liu, M.;Liu, Y.;Zhang, Z.;Bai, Z.

通讯作者：

Bai, Z

作者机构：

[Wang, Q.; Zhang, Z.] Hunan Univ Chinese Med, Dept Grad Sch, Changsha, Peoples R China.

[Liu, M.; Bai, Z.; Liu, Y.] Hunan Acad Chinese Med, Dept Resp Med, Affiliated Hosp, Changsha, Peoples R China.

通讯机构：

[Bai, Z ] H

Hunan Acad Chinese Med, Dept Resp Med, Affiliated Hosp, Changsha, Peoples R China.

语种：

英文

关键词：

cigarette smoke;lipopolysaccharide;pulmonary microvascular endothelial cell;pyroptosis;pulmonary arterial hypertension

期刊：

Bulletin of Experimental Biology and Medicine

ISSN：

0007-4888

年：

2023

卷：

174

期：

页码：

728-733

DOI：

10.1007/s10517-023-05780-8

基金类别：

National Natural Science Foundation of China [81874459]

机构署名：

本校为第一且通讯机构

摘要：

We studied the effect of cigarette smoke extract (CSE), LPS, or their combination on the activity and pyroptosis of pulmonary microvascular endothelial cells (PMVEC) in rats. PMVEC were cultured without treatment, with CSE in different concentrations (1-25%), with 20 ng/ml LPS, or with 20% CSE+20 ng/ml LPS. Cell viability was determined using the CCK8 kit, apoptosis was evaluated by flow cytometry, and cell morphology was evaluated using light microscopy. The content of IL-1β and IL-18 was measured by ELISA. CSE decreased cell viability in a d...

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Cigarette Smoke Extract and Lipopolysaccharide Induce Pyroptosis in Pulmonary Microvascular Endothelial Cells of Rats

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