[Liu, Wanhui; Liu, RX; Liu, Rongxia; Liu, Qianqian] Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm, Minist Educ,Collaborat Innovat Ctr Adv Drug Deliv, Yantai 264005, Peoples R China.

[Cai, Xiong; Li, Bin; Wang, Wei; Liu, Leping] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Innovat Mat Med Res Inst, Changsha 410208, Hunan, Peoples R China.

[Cheng, Dongsheng] Yantai Yuhuangding Hosp, Yantai 264000, Peoples R China.

[Liu, RX ] Y

[Wang, W ] H

Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm, Minist Educ,Collaborat Innovat Ctr Adv Drug Deliv, Yantai 264005, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Innovat Mat Med Res Inst, Changsha 410208, Hunan, Peoples R China.

carboxyl group;lactone derivative;methanol;schisanlactone e;unclassified drug;herbaceous agent;schisanlactone E;triterpene;accuracy;animal experiment;area under the curve;Article;dehydrogenation;drug bioavailability;drug excretion;drug metabolism;half life time;hydrophilicity;hydroxylation;in vivo study;isomer;Kadsura;Kadsura heteroclita;male;matrix effect;maximum plasma concentration;mean residence time;multiple reaction monitoring;nonhuman;physical chemistry;plasma concentration-time curve;precipitation;priority journal;qualitative analysis;quantitative analysis;rat;solid phase extraction;sulfation;supernatant;tandem mass spectrometry;time to maximum plasma concentration;ultra performance liquid chromatography;volume of distribution;animal;animal model;bioavailability;chemistry;feces;high performance liquid chromatography;intestinal excretion;Kadsura;oral drug administration;plant stem;procedures;tandem mass spectrometry;urinary excretion;Administration, Oral;Animals;Biological Availability;Chromatography, High Pressure Liquid;Drugs, Chinese Herbal;Feces;Intestinal Elimination;Kadsura;Male;Models, Animal;Plant Stems;Rats;Renal Elimination;Solid Phase Extraction;Tandem Mass Spectrometry;Triterpenes

药学院