期刊论文

An Experimental Study on the Preconditioning Effects of Supplemented Salvia Beverage on the Cardiac Function of Rabbits with Ischemia Reperfusion Injury

中文

湖南中医药大学学报

1674-070X

2003

23

6

4-6

10.3969/j.issn.1674-070X.2003.06.002

湖南省自然科学基金资助课题 （ 0 1JJY2 0 3 9）；

本校为第一机构

目的探讨加味丹参饮预处理对缺血再灌注损伤家兔心功能的影响.方法32只健康家兔,随机分为假手术组(Sham)、缺血再灌注组(I/R)、加味丹参饮预处理组(DP)和缺血预处理组(IP),每组8只,分别预处理24h后行心肌缺血60min,再灌注120min,观察家兔左室收缩压(LVSP)、左室舒张期末压(LVDP)、左室压力最大上升速率(+dp/dtmax)、最大下降速率(-dp/dtmax).结果DP和IP对缺血再灌注所致的LVSP和LVDP下降有显著的抑制作用,其中DP对LVDP作用尤为明显.两者对+dp/dtmax和-dp/dtmax变化无明显的影响.结论加味丹参饮预处理对缺血再灌注损伤家兔心功能改变具有调节作用.

Objective To investigate the preconditoning effects of Supplemented Salvia Beverage(SSB) on the cardiac function of rabbits with ischemia reperfusion(I/R) injury. Methods Thirty-two rabbits were included in this I/R study.They were randomly divided into four groups,i.e. Sham group(SG), I/R group(I/RG),SSB group(SSBG) and ischemia preconditioning group(IPG) and treated respectively with saline, SSB at a dosage of 5.86g/kg and ischemia for 5 min.by coronary artery occlusion followed reperfusion for 10 min. as a cycle.Then,observed were the parameners including left ventricle systolic pressure(LV...