Carboxylation of multiwalled carbon nanotube attenuated the cytotoxicity by limiting the oxidative stress initiated cell membrane integrity damage, cell cycle arrestment, and death receptor mediated apoptotic pathway

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成果类型：

期刊论文

作者：

Liu, Zhenbao;Liu, Yanfei;Peng, Dongming*

通讯作者：

Peng, Dongming

作者机构：

[Liu, Zhenbao] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Changsha 410013, Hunan, Peoples R China.

[Liu, Yanfei] Cent S Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Changsha 410013, Hunan, Peoples R China.

[Peng, Dongming] Hunan Univ Chinese Med, Sch Pharm, Dept Med Chem, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Peng, Dongming] H

Hunan Univ Chinese Med, Sch Pharm, Dept Med Chem, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

multiwalled carbon nanotubes;oxidative stress;cell membrane integrity;cell cycle death receptor

期刊：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

ISSN：

1549-3296

年：

2015

卷：

103

期：

页码：

2770-2777

DOI：

10.1002/jbm.a.35416

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81301258]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [13JJ4029]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20130162120078]; Postdoctoral Science Foundation of Central South University and China [124896]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2013M540644]; International Postdoctoral Exchange Fellowship Program [29, 20140014]; Natural Science Foundation of Hunan Province-Zhuzhou City United, China [12JJ9046]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Abstract In this study, the effects of carboxylated multiwalled carbon nanotubes (MWCNTs‐COOH) on human normal liver cell line L02 was compared with that of pristine multiwalled carbon nanotubes (p‐MWCNTs). It was shown that compared with MWCNTs‐COOH, p‐MWCNTs induced apoptosis, reduced the level of intracellular antioxidant glutathione more significantly, and caused severer cell membrane damage as demonstrated by lactate dehydrogenase leakage. Cell cycles were arrested by both MWCNTs, while p‐MWCNTs induced higher ratio of G0/G1 phase arr...

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Carboxylation of multiwalled carbon nanotube attenuated the cytotoxicity by limiting the oxidative stress initiated cell membrane integrity damage, cell cycle arrestment, and death receptor mediated apoptotic pathway

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