期刊论文

Ning, Yi;Lu, FG

英文

Revista Brasileira de Farmacognosia

0102-695X

2022

32

3

455-459

10.1007/s43450-022-00242-0

National Natural Science Foundation [81803964, 82074250]; Natural Science Foundation of Hunan Province [2020JJ4465, 2020JJ4063]; First-Class Cultivation Subject of Integrated Chinese and Western Medicine in Hunan Province; Research and Innovation Program for Postgraduates in Hunan Province [CX20210700]; First-Class Open Foundation Funded for Integrated Chinese and Western Medicine [2020ZXYJH52]; Key Project of the Department of Education of Hunan Province [21A0237]; Xinglin Talent Cultivation Program; Basic Medicine Construction Project of Hunan University of Traditional Chinese Medicine [6]; Excellent Teaching Team of Postgraduate in Hunan Province (Teaching Team of Postgraduate in Basic Medicine) [[2019] 370-118]; Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine [2019TP1044]

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This study investigated the effect and possible mechanism of berberine on biofilm formation by methicillin-resistant Staphylococcus aureus. Compared with chloramphenicol, berberine showed a significantly stronger inhibitory effect on the growth of methicillin-resistant Staphylococcus aureus, and the minimum inhibition concentration and minimum bactericidal concentration for berberine were 0.05 mg/ml and 0.1 mg/ml, respectively (p < 0.05). In addition, berberine significantly impaired biofilm formation and reduced biofilm thickness in a dose-dependent manner (p < 0.05). Furthermore, the results...