Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations

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成果类型：

期刊论文

作者：

Liao, Xiaolin;Han, Yuanshan;Shen, Chuanpu;Liu, Jianjun*;Wang, Yuhong

通讯作者：

Liu, Jianjun;Wang, YH;Shen, CP

作者机构：

[Liu, Jianjun; Liao, Xiaolin; Liu, JJ; Wang, Yuhong] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Han, Yuanshan] Hunan Univ Chinese Med, Sci Res Dept, Hosp 1, Changsha, Peoples R China.

[Shen, Chuanpu; Shen, CP] Anhui Med Univ, Anhui Inst Innovat Drugs, Sch Pharm, Anhui Prov Key Lab Major Autoimmune Dis, Hefei 230032, Peoples R China.

[Shen, Chuanpu] Anhui Med Univ Hefei, Minist Educ, Key Lab Antiinflammatory & Immune Med, Inst Liver Dis, Hefei, Peoples R China.

通讯机构：

[Shen, CP ] A

[Liu, JJ; Wang, YH ] H

Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha 410208, Hunan, Peoples R China.

Anhui Med Univ, Anhui Inst Innovat Drugs, Sch Pharm, Anhui Prov Key Lab Major Autoimmune Dis, Hefei 230032, Peoples R China.

语种：

英文

关键词：

formulations;hypertension;natural products;NLRP3 inflammasome;target organ damage

期刊：

Phytotherapy Research

ISSN：

0951-418X

年：

2023

DOI：

10.1002/ptr.8009

基金类别：

This work was supported by the National Natural Science Foundation of China (81874464; 82174357), the Education Department Scientific Research Foundation of Hunan Province of China (18A228), and Innovation Project of Hunan University of Chinese Medicine (N [82174357, 18A228]; National Natural Science Foundation of China [2023CX04]; Education Department Scientific Research Foundation of Hunan Province of China; Innovation Project of Hunan University of Chinese Medicine; [81874464]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

A schematic overview of the process of NLRP3 inflammasome action on hypertensive target organ damage and the intervention of natural products and formulations. Abstract Background and Aim Hypertension is a major global health problem that causes target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms of hypertensive TOD are not fully understood, and its treatment is challenging. This review provides an overview of the current knowledge on the role of Nod‐like receptor pyrin domain containing 3 (NLRP3) inflammas...

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Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations

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