The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer

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成果类型：

期刊论文

作者：

Luo, Qianxuan;Wu, Ting;Wu, Wenfang;Chen, Gong;Luo, Xuan;...

通讯作者：

Deng, Meichun

作者机构：

[Chen, Gong; Wu, Wenfang; Deng, Meichun; Luo, Qianxuan; Wu, Ting; Kang, Shuntong] Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Changsha, Peoples R China.

[Chen, Gong; Wu, Wenfang; Deng, Meichun; Luo, Qianxuan; Wu, Ting; Kang, Shuntong] Cent South Univ, Sch Life Sci, Hunan Prov Key Lab Basic & Appl Hematol, Changsha, Peoples R China.

[Deng, Meichun; Luo, Qianxuan] Cent South Univ, Sch Life Sci, Hunan Key Lab Anim Models Human Dis, Changsha, Peoples R China.

[Deng, Meichun; Luo, Qianxuan] Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Changsha, Peoples R China.

[Jiang, Liping; Wu, Ting; Kang, Shuntong] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China.

通讯机构：

[Deng, Meichun] C

Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Changsha, Peoples R China.

Cent South Univ, Sch Life Sci, Hunan Prov Key Lab Basic & Appl Hematol, Changsha, Peoples R China.

Cent South Univ, Sch Life Sci, Hunan Key Lab Anim Models Human Dis, Changsha, Peoples R China.

Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Changsha, Peoples R China.

语种：

英文

关键词：

Voltage-gated sodium channel (VGSC) Nav1.5;breast cancer;metastasis;Mechanism;inhibitors

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2020

卷：

页码：

527711

DOI：

10.3389/fphar.2020.01111

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31672290, 31100764, 31971190, 30901874, 81503276]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2016JJ3180]; Valuable Instrument and Equipment Fund of Central South University [CSUZC2019046, CSUZC2020043]

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are involved in the metastatic process of invasion and migration. Nav1.5 is a pore-forming alpha subunit of VGSC encoded bySCN5A. Various studies have demonstrated that Nav1.5, often as its neonatal splice form, is highly expressed in metastatic breast cancer cells. Abnormal activation and expression of Nav1.5 trigger a variety of cellular mechanisms, including changing H(+)efflux, promoting epithelial-to-mesenchymal transit...

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The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer

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