An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Yalan;Zhang, Yanling;Wu, Yongjun;Xiang, Qin;Yu, Rong

通讯作者：

Yu, R.;Xiang, Q.

作者机构：

[Huang, Yalan; Yu, Rong] Hunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China.

[Huang, Yalan] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha 410021, Peoples R China.

[Zhang, Yanling] Hunan Univ Tradit Chinese Med, Coll Tradit Chinese Med, Changsha 410208, Peoples R China.

[Zhang, Yanling] Ningxia Med Univ, Gen Hosp, Ningxia 750003, Peoples R China.

[Wu, Yongjun] Hunan Univ Tradit Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.

通讯机构：

[Qin Xiang] S

[Rong Yu] G

Science and Technology Department, Hunan University of Traditional Chinese Medicine, Changsha, 410208, People’s Republic of China<&wdkj&>Graduate School, Hunan University of Traditional Chinese Medicine, Changsha, 410208, People’s Republic of China

语种：

英文

关键词：

apoptosis;diabetic cardiomyopathy;network pharmacology;pharmacochemistry;PI3K/Akt pathway;Zuogui Jiangtang Shuxin formula

期刊：

Drug Design, Development and Therapy

ISSN：

1177-8881

年：

2023

卷：

页码：

237-260

DOI：

10.2147/DDDT.S390883

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (82074400), Hunan Provincial Technology Key Research and Development Program (2020SK2101), National Natural Science Foundation of China (82004185), National Natural Science Foundation of China (U21A20411), Postgraduate Research and Innovation Project of Hunan Province (CX20210692), and Hunan Provincial Key Laboratory of Translational Medicine for TCM Recipe and Syndrome Research (2018TP1021).

机构署名：

本校为第一机构

院系归属：

中医学院

第一中医临床学院

药学院

研究生院

摘要：

Purpose: This study aimed to explore the mechanism of Zuogui Jiangtang Shuxin formula (ZGJTSXF) in the treatment of diabetic cardiomyopathy (DCM) by an integrative strategy combining serum pharmacochemistry, network pharmacology analysis, and experimental validation. Methods: An Ultra high performance liquid chromatography-high resolution mass spectrometry (UPLC-Q-Exactive-Orbitrap-MS) method was constructed to identify compounds in rat serum after oral administration of ZGJTSXF. A component-target network between the targets of ZGJTSXF ingredi...

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An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy

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