National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372068, 21572049]; Science and Technology Program of Hunan Province, China [2014GK3115]; Science and Technology Program of Changsha, China [K1508004-11]
机构署名：
本校为其他机构
院系归属：
药学院
摘要：
A convenient synthetic approach for the synthesis of α-oxo-acetamidines via copper-catalyzed C(sp 3 )-H amidination has been developed. This approach allows the direct amidination of three C(sp 3 )-H bonds without cyclization.Methyl ketones and primary and secondary amines are tolerant and afford the corresponding products in moderate to good yields. Furthermore, this protocol is also applicable to the synthesis of unsymmetrical α-oxo-acetamidines via one-pot, multicomponent reaction...
