Astragaloside IV drug-loaded exosomes (AS-IV EXOs) derived from endothelial progenitor cells improve the viability and tube formation in high-glucose impaired human endothelial cells by promoting miR-214 expression

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成果类型：

期刊论文

作者：

Zou, Xiaoling;Xiao, Hui;Bai, Xue;Zou, Yixian;Hu, Wenxiao;...

作者机构：

[Hu, Wenxiao; Bai, Xue; Xiao, Hui; Zou, Xiaoling; Zou, Yixian; Lin, Xiangdong] Hunan Univ Chinese Med, Dept Endocrinol, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

[Zhu, Chenhong; Liang, Yao] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.

[Xiong, Wu] Hunan Univ Chinese Med, Dept Burns & Plast Surg, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

astragaloside IV;endothelial cells;miR-214;exosomes;tube formation;diabetes mellitus

期刊：

Endokrynologia Polska

ISSN：

0423-104X

年：

2022

卷：

期：

页码：

336-345

DOI：

10.5603/EP.a2022.0011

基金类别：

Scientific Research Project of Hunan Provincial Health Commission [20201388]; National Natural Science Foundation of China Youth Science Fund Project [81904217]

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

Introduction: The high glucose changes caused by diabetes mellitus (DM) can damage the vascular system. Astragaloside IV (AS-IV) can improve diabetes and promote angiogenesis. Exosomes (EXOs) help to carry specific drugs into cells efficiently. However, whether AS-IV loaded EXOs (AS-IV EXOs) can improve damaged endothelial cells through miR-214 remains to be determined. Material and methods: We prepared and identified AS-IV EXOs derived from endothelial progenitor cells (EPCs) and high glucose stimulated endothelial cell models to investigate whether AS-IV EXOs can improve damaged endothelial ...

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Astragaloside IV drug-loaded exosomes (AS-IV EXOs) derived from endothelial progenitor cells improve the viability and tube formation in high-glucose impaired human endothelial cells by promoting miR-214 expression

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