期刊论文

The Effect of Yangxintongmai Tablet on the Area of Atherosclerosis Plaque, the Expression of bFGF and the New Vessels in Rabbits with Atherosclerosis

中文

中西医结合心脑血管病杂志

1672-1349

2006

4

10

886-888

10.3969/j.issn.1672-1349.2006.10.023

本课题为教育部博士点基金项目（No.20050541005）

本校为第一机构

目的 观察养心通脉片对动脉粥样硬化白兔斑块面积、碱性成纤维细胞生长因子(bFGF)表达和新生血管数的影响和机制.方法 利用高脂饲料喂养白兔造模,模型组用双蒸水灌胃,养心通脉片组用养心通脉片药液灌胃,辛伐他汀片组用辛伐他汀片药液灌胃.1个月后,取白兔主动脉,常规染色观察斑块面积,免疫组化法观察bFGF表达和新生血管数.结果 养心通脉片组、辛伐他汀片组与模型组主动脉斑块面积比较有统计学意义(P＜0.01);3组斑块中均可见棕黄色bFGF表达,养心通脉片组和辛伐他汀片组表达较少,与模型组比较有统计学意义(P＜0.05);3组斑块中均可见＞10μm的颗粒,养心通脉片组与辛伐他汀片组颗粒较少,与模型组比较...

Objective To investigate the effect and the mechanism of Yangxintongmai（YXTM） on the area of atherosclerosis （AS） plaque, the expression of bFGF and the numbers of new vessels in rabbits with atherosclerosis. Methods Twenty-four rabbits were divided into model group, YXTM group and simvastatin group. Results The area of AS plaque were smaller in YXTM group and the simvastatin group than that in the model group（ P〈0.01 ）. The yellow positive expressions smaller in YXTM group and simvastatin group than that in model group （P〈0.05 ）. Con...