期刊论文

Experimental study on the improvement of inflammatory response in rats with cerebral ischemia by Chinese ultrasound drug permeation electrotherapy device

中文

国际中医中药杂志

1673-4246

2023

45

1

54-59

10.3760/cma.j.cn115398-20220621-00265

本校为第一机构

目的:观察中医超声药透电疗仪对脑缺血大鼠炎症反应的影响，为中医超声药透电疗仪治疗脑缺血的临床应用提供实验依据。方法:将72只SD大鼠按随机分组法分为假手术组12只和造模组60只，造模组采用线栓法制备大脑中动脉闭塞（MCAO）模型。将造模成功大鼠按随机数字表法分为模型组、中药片组、空白片+中医超声药透电疗仪组（以下简称“空白片+电疗组”）、中药片+中医超声药透电疗仪组（以下简称“中药片+电疗组”）、丁苯酞组，每组12只。连续给予相应干预7 d后，进行神经功能评分；TTC染色观察脑梗死体积，并计算脑梗死体积；HE染色观察各组大鼠皮质区细胞形态；采用ELISA法检测各组大鼠血清TNF-α...

Objective:To observe the effects of Traditional Chinese Medicine (TCM)ultrasound drug permeation electrotherapy device on the inflammatory response of rats with cerebral ischemia, and to provide an experimental basis for the clinical application of TCM ultrasound drug permeation electrotherapy device in the treatment of cerebral ischemia.Methods:A total of 72 SD rats were randomly divided into sham-operation group (12 rats) and modeling group (60 rats). The middle cerebral artery occlusion (MCAO) model was prepared by thread embolism in the mod...