Establishment and Evaluation of a Rat Model of Spinal Cord Injury with the Pathopattern of Qi-Deficiency and Blood-Stasis in Traditional Chinese Medicine

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成果类型：

期刊论文

作者：

李亮;李丰;殷坚;潘波;余清平;...

通讯作者：

Huang, H.-Y.

作者机构：

[黄惠勇; 蔡雄] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

[余清平; 潘波; 陈安; 殷坚] Key Discipline of Anatomy and Histoembryology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

School of Dentistry, University of California Los Angeles, California, CA 9005, United States

[李丰] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, School of Dentistry, University of California Los Angeles, California, CA 9005, United States

[李亮] Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, Key Discipline of Anatomy and Histoembryology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

通讯机构：

[Huang, H.-Y.] P

Provincial Key Laboratory of TCM Diagnostics, China

语种：

中文

关键词：

脊髓损伤;气虚血瘀;补阳还五汤;红核脊髓束

关键词(英文)：

Spinal cord injury (SCI);Qi-deficiency and Blood-stasis (QDBS);Bu Yang Huan Wu Decoction (BYHWD);Rubrospinal tract (RST)

期刊：

数字中医药(英文)

ISSN：

2096-479X

年：

2018

卷：

期：

页码：

102-112

DOI：

10.1016/S2589-3777(19)30012-6

基金类别：

We thank for the funding support from the National Natural Science Foundation of China (No. 81302899, 81373551 and 81603512) and the Key Science and Research Program of Hunan Department of Science and Technology (No. 2012TF-1005).

机构署名：

本校为第一机构

院系归属：

中医诊断研究所

摘要：

目的制备脊髓损伤（SCI）气虚血瘀证大鼠模型,评价该模型的合理性。方法采用游泳力竭法联合红核脊髓束（RST）横断手术制备SCI气虚血瘀证大鼠模型,通过观察中医宏观表征、肢体行为学、血液流变学及脊髓组织形态,结合益气活血中药复方补阳还五汤（BYHWD）进行反证,最终评价该模型的合理性。结果气虚血瘀组大鼠体重、摄食量和前肢使用率降低,舌象评分上升,符合气虚血瘀证的表现;35 d后BYHWD组各指标均优于气虚血瘀组。与正常组相比,气虚血瘀组全血黏度、红细胞压积上升（P

摘要(英文)：

Objective To establish a rat model of Spinal Cord Injury (SCI) with the pathopattern of Qi-deficiency and Blood-stasis (QDBS) in Traditional Chinese Medicine (TCM), and then assess its feasibility. Methods Swimming exhaustion method and Rubrospinal Tract (RST) transection were combined to establish arat model of SCI with pathopattern of QDBS in TCM. Macroscopic representation, including the body weight, food intake and tongue scores, was recorded. Behavioristics was scored with spontaneous vertical exploration test. Hemorrheology was analyzed u...

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Establishment and Evaluation of a Rat Model of Spinal Cord Injury with the Pathopattern of Qi-Deficiency and Blood-Stasis in Traditional Chinese Medicine

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