A pH-Driven indomethacin-loaded nanomedicine for effective rheumatoid arthritis therapy by combining with photothermal therapy

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成果类型：

期刊论文

作者：

Hu, Shengtao;Lin, Ye;Tong, Chunyi;Huang, Hong;Yi, Ouyang;...

通讯作者：

Cai, X;Liu, B

作者机构：

[Cai, Xiong; Hu, Shengtao; Su, Zhaoli; Cai, X; Yi, Ouyang; Dai, Zongsun; Lin, Ye; Huang, Hong] Hunan Univ Chinese Med, Hosp 1, Inst Innovat & Appl Res Chinese Med, Changsha, Hunan, Peoples R China.

[Cai, Xiong; Hu, Shengtao; Su, Zhaoli; Cai, X; Yi, Ouyang; Dai, Zongsun; Lin, Ye; Huang, Hong] Hunan Univ Chinese Med, Hosp 1, Dept Rheumatol, Changsha, Hunan, Peoples R China.

[Liu, Bin; Liu, B; Tong, Chunyi] Hunan Univ, Coll Biol, Changsha, Hunan, Peoples R China.

通讯机构：

[Liu, B ; Cai, X ] H

Hunan Univ Chinese Med, Hosp 1, Inst Innovat & Appl Res Chinese Med, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Hosp 1, Dept Rheumatol, Changsha, Hunan, Peoples R China.

Hunan Univ, Coll Biol, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Rheumatoid arthritis;indomethacin;Prussian blue nanoparticles;targeted delivery;biomimetic membrane;photothermal therapy

期刊：

Journal of Drug Targeting

ISSN：

1061-186X

年：

2022

卷：

期：

页码：

737-752

DOI：

10.1080/1061186X.2022.2053539

基金类别：

This study was funded by grants from the Science and Technology Innovation Megaproject and Science and Technology Innovation Program of Hunan Province (2020SK1020 and XKJ[2021]43-2021RC4035). Additionally, this work was supported by the Hunan Furong Distinguished Scholar Program (XJT[2020]58), Hunan 121 Training Project for Innovative Talents (XRSH[2019]192), Chinese Academy of Engineering Academician Liang Liu’s Workstation of Hunan University of Chinese Medicine (HNUCM) (XKXT[2020]34), and the National First-class Disciple Construction Project of Chinese Medicine of HNUCM (XXKZ[2018]3).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by inflammatory micro-environments in the joints. Indomethacin (IND), a conventional nonsteroidal anti-inflammatory drug (NSAID), has been used for the therapy of RA. However, the poor solubility and serious side effects of oral administration of IND significantly limit its efficacy. In this study, we have synthesized biomimetic IND-loaded Prussian blue (PB) nanoparticles (IND@PB@M@HA) with hyaluronic acid (HA) modification for increasing the solubility and targeting the ability of IND to the inflamed joints. The applicat...

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A pH-Driven indomethacin-loaded nanomedicine for effective rheumatoid arthritis therapy by combining with photothermal therapy

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