期刊论文

Effect of Electroacupuncture on Colonic IL-1β and nAchRa7mRNA in Ulcerative Colitis Rats

中文

上海针灸杂志

1005-0957

2016

35

10

1251-1255

10.13460/j.issn.1005-0957.2016.10.1251

国家自然科学基金项目（81173327/H2718）；

本校为第一机构

目的：对比观察电针溃疡性结肠炎大鼠上巨虚、足三里、下巨虚、阳陵泉等穴后对结肠组织白介素-1b(IL-1b)及烟碱型乙酰胆碱受体a7信使核糖核酸(nAchRa7mRNA)表达的影响,探讨大肠下合穴上巨虚治疗对应腑病是否存在相对特异性。方法将70只健康 SD 大鼠随机分为空白组、模型组、上巨虚组、足三里组、下巨虚组、阳陵泉组及承筋组,每组10只,雌雄各半。除空白组外均采用2-4-6三硝基苯磺酸/乙醇溶液灌肠诱导建立大鼠溃疡性结肠炎模型,造模成功并治疗10 d后,肉眼观察大鼠结肠黏膜溃疡及炎症情况,ELISA法检测大鼠结肠组织中IL-1b含量,RT-PCR检测nAchRa7mRNA的表达。结果与模型组比,各穴位组结肠损伤有不同...

Objective To compare the effects of electroacupuncture at points Shangjuxu(ST37), Zusanli(ST36), Xiajuxu(ST39) and Yanglingquan(GB34) on colonic expressions of interleukin-1b (IL-1b) and nicotinic acetylcholine receptor a7 mRNA (nAchRa7mRNA) in ulcerative colitis rats and investigate if large intestine lower He-Sea point Shangjuxu has relative specificity to fu organ diseases. Method Seventy healthy SD rats were randomized into blank, model, Shangjuxu, Zusanli, Xiajuxu, Yanglingquan and Chengjin groups, 10 rats, half male and half female, each. A rat model of ulcerative colitis was made by ind...