Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiao, Guiying;Yuan, Fang;Deng, Yang;Xiang, Debiao;Xiong, Liguang;...

作者机构：

[Xiao, Guiying; Xiong, Liguang; Li, Yuan; Yuan, Fang; Deng, Yang; Xiang, Debiao; Li, Xin] Third Hosp Changsha, Dept Pharm, Changsha, Hunan, Peoples R China.

[Xiao, Guiying; Xiong, Liguang; Li, Yuan; Yuan, Fang; Deng, Yang; Xiang, Debiao; Li, Xin] Third Hosp Changsha, Inst Clin Applicat Antibiot, Changsha, Hunan, Peoples R China.

[Xiao, Guiying; Xiong, Liguang; Li, Xin] Hunan Univ Chinese Med, Hosp Changsha 3, Dept Pharm, Changsha, Hunan, Peoples R China.

[Li, Yuan; Li, Xin] Third Hosp Changsha, Dept Pharm, 176 Western Laodong Rd, Changsha 410015, Hunan, Peoples R China.

语种：

英文

关键词：

Nrf2/NQO1 pathway;apoptosis;nephrotoxicity;oxidative stress;polymyxin B

期刊：

Journal of Biochemical and Molecular Toxicology

ISSN：

1095-6670

年：

2023

卷：

期：

页码：

e23344

DOI：

10.1002/jbt.23344

基金类别：

Department of Science and Technology of Hunan Province [2016SK4008]; Changsha Science and Technology Project [kq2208464, kzd2001096]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Polymyxin B (PMB) is a polypeptide antibiotic widely used in treating multidrug-resistant Gram-negative bacteria. However, nephrotoxicity is a serious adverse effect that limits its clinical use. Therefore, clarification of the molecular mechanism of PMB-induced renal injury is essential. Our study aimed to explore possible mechanisms of PMB-induced nephrotoxicity in vivo and in vitro. Mice were treated with PMB to construct the kidney injury model. The antioxidant capacity was assessed by measuring the superoxide dismutase (SOD) and catalase (CAT) activities and the glutathione (GSH)and malon...

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Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response

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