Network Pharmacology-Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.-Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy

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成果类型：

期刊论文

作者：

Zhang, Shiying;Yuan, Zhiying;Wu, Huaying;Li, Weiqing*;Li, Liang*;...

通讯作者：

Li, Liang;Huang, Huiyong;Li, Weiqing

作者机构：

[Yuan, Zhiying; Wu, Huaying; Li, Liang; Huang, Huiyong; Zhang, Shiying] Hunan Univ Chinese Med, Changsha, Peoples R China.

[Zhang, Shiying; Li, Weiqing] Shenzhen Luohu Peoples Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.

[Zhang, Shiying; Li, Weiqing] Shenzhen Univ, Dept Tradit Chinese Med, Affiliated Hosp 2, Shenzhen, Peoples R China.

[Zhang, Shiying; Li, Weiqing] Shenzhen Luohu Peoples Hosp, Shenzhen Luohu Hosp Grp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.

通讯机构：

[Li, L; Huang, HY] H

[Li, Weiqing] S

Hunan Univ Chinese Med, Changsha, Peoples R China.

Shenzhen Luohu Peoples Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.

Shenzhen Univ, Dept Tradit Chinese Med, Affiliated Hosp 2, Shenzhen, Peoples R China.

语种：

英文

期刊：

BioMed Research International

ISSN：

2314-6133

年：

2020

卷：

2020

DOI：

10.1155/2020/8260703

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81603512, 81874429]; Postgraduate Scientific Research Innovation Project of Hunan Province of China [CX20190536, CX20190591, CX2018B465, CX2017B428]; Natural Science Foundation of Hunan Province of ChinaNatural Science Foundation of Hunan Province [2018JJ2289]; innovation project for graduate students of Hunan University of Chinese Medicine [2018CX05, 2018CX25]; Postgraduate Scientific Research Innovation Project of Guangdong Yifang Pharmaceutical Co., Ltd [yf201708]

机构署名：

本校为第一且通讯机构

摘要：

Objective. To explore the effects of the Hedysarum multijugum Maxim.-Radix Salviae compound (Huangqi-Danshen Compound (HDC)) on oxidative capacity and cardiomyocyte apoptosis in rats with diabetic cardiomyopathy by a network pharmacology-based strategy. Methods. Traditional Chinese Medicine (TCM)@Taiwan, TCM Systems Pharmacology Database and Analysis Platform (TCMSP), TCM Integrated Database (TCMID), and High-Performance Liquid Chromatography (HPLC) technology were used to obtain and screen HDC's active components, and the PharmMapper database was used to predict HDC human target protein targe...

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Network Pharmacology-Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.-Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy

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